【Patent Number: No. 7497094】Composition for Improving Gut Microbiota and Its Applications
May 31, 2024: New Patent Acquisition
We obtained a new patent right on May 31, 2024. Mesenchymal stem cells are expected to have various therapeutic effects, such as anti-inflammatory effects, and numerous studies have been conducted to treat intractable diseases. Among them, our company has discovered that using the conditioned medium (cell culture supernatant) derived from human MSCs (MSC-CM), which contains the secretions of mesenchymal stem cells, is potentially able to improve the gut microbiota, and obtained a patent right based on this discovery. The various therapeutic effects of mesenchymal stem cells may be mediated through the improvement of the gut microbiota, and this patent is also considered to be a fundamental one.
Patent Overview
- Title of Invention: Composition for Improving Gut Microbiota and Its Applications （https://www.j-platpat.inpit.go.jp/c1801/PU/JP-7497094/15/ja）
- Patent Number: No. 7497094 / Patent Holder: BioMimetics Sympathies, Inc.
- Application Date: September 7, 2023 / Registration Date: May 31, 2024
About Gut Microbiota
It is thought that about 1,000 species/100 trillion gut bacteria inhabit the human intestine (mainly the large intestine). Various bacteria exist while maintaining a balance and are thought to contribute to maintaining the host’s homeostasis. Recently, it has been reported that the phenomenon of imbalance (called Dysbiosis) is strongly related not only to intestinal diseases, such as inflammatory bowel disease, but also to cardiovascular diseases and dementia, and research is being actively conducted worldwide.
About the conditioned medium/cell culture supernatant
To culture cells, it is necessary to use a culture medium (liquid) for cell culture, in which cells proliferate. During the proliferation process, various secretory factors are released from the cells. The culture medium containing these secretions from the cells is called the conditioned medium/cell culture supernatant. Among various cells, mesenchymal stem cells that our company is researching are known to secrete various growth factors, cytokines, and exosomes with high therapeutic effects into the culture medium.